The design and synthesis of guanosine compounds with in vitro activity against the colon cancer cell line SW480: non-Taxane derived mimics of taxol?

J Howarth, P Kenny, S McDonnell…

Index: Bioorganic and Medicinal Chemistry Letters, , vol. 13, # 16 p. 2693 - 2697

Full Text: HTML

Citation Number: 14

Abstract

... Please enable JavaScript to use all the features on this page. Bioorganic & Medicinal Chemistry Letters. ... Guanosine is a cheap and readily available chemical, and the isoserine side-chain 6a has been synthesized several times, by various routes. ...

 Related Synthetic Route
Bz-RS-iSer(3-Ph)-OMe Structure

32981-85-4

Bz-RS-iSer(3-Ph)-OMe

~%

(4S,5R)-3,5-Oxazolidinecarboxylic acid, 3-benzoyl-2,2-dimethy1-4-pheny1 Structure

153652-70-1

(4S,5R)-3,5-Oxa...

2-Propenoic acid, 3-phenyl-, 1-Methylethyl ester, (2E)- Structure

60512-85-8

2-Propenoic aci...

~%

(4S,5R)-3,5-Oxazolidinecarboxylic acid, 3-benzoyl-2,2-dimethy1-4-pheny1 Structure

153652-70-1

(4S,5R)-3,5-Oxa...

(2R,3S)-3-Amino-3-phenyl-1,2-propanediol Structure

136561-53-0

(2R,3S)-3-Amino...

~%

(4S,5R)-3,5-Oxazolidinecarboxylic acid, 3-benzoyl-2,2-dimethy1-4-pheny1 Structure

153652-70-1

(4S,5R)-3,5-Oxa...

Benzoyl chloride Structure

98-88-4

Benzoyl chloride

~%

(4S,5R)-3,5-Oxazolidinecarboxylic acid, 3-benzoyl-2,2-dimethy1-4-pheny1 Structure

153652-70-1

(4S,5R)-3,5-Oxa...

(2R,3S)-3-amino-2-hydroxy-3-phenylpropionic acid methyl ester Structure

157240-36-3

(2R,3S)-3-amino...

~%

(4S,5R)-3,5-Oxazolidinecarboxylic acid, 3-benzoyl-2,2-dimethy1-4-pheny1 Structure

153652-70-1

(4S,5R)-3,5-Oxa...

(2R,3S)-3-acetylamino-2-hydroxy-3-phenylpropanoic acid isopropyl ester Structure

195624-97-6

(2R,3S)-3-acety...

~%

(4S,5R)-3,5-Oxazolidinecarboxylic acid, 3-benzoyl-2,2-dimethy1-4-pheny1 Structure

153652-70-1

(4S,5R)-3,5-Oxa...

(2R,3S)-3-acetylamino-2-hydroxy-3-phenylpropanoic acid isopropyl ester Structure

195624-97-6

(2R,3S)-3-acety...

~%

(2R,3S)-3-Amino-3-phenyl-1,2-propanediol Structure

136561-53-0

(2R,3S)-3-Amino...

2-Propenoic acid, 3-phenyl-, 1-Methylethyl ester, (2E)- Structure

60512-85-8

2-Propenoic aci...

~%

(2R,3S)-3-Amino-3-phenyl-1,2-propanediol Structure

136561-53-0

(2R,3S)-3-Amino...

2-Propenoic acid, 3-phenyl-, 1-Methylethyl ester, (2E)- Structure

60512-85-8

2-Propenoic aci...

~%

Bz-RS-iSer(3-Ph)-OMe Structure

32981-85-4

Bz-RS-iSer(3-Ph)-OMe

(2R,3S)-3-Amino-3-phenyl-1,2-propanediol Structure

136561-53-0

(2R,3S)-3-Amino...

~%

Bz-RS-iSer(3-Ph)-OMe Structure

32981-85-4

Bz-RS-iSer(3-Ph)-OMe

(2R,3S)-3-acetylamino-2-hydroxy-3-phenylpropanoic acid isopropyl ester Structure

195624-97-6

(2R,3S)-3-acety...

~%

Bz-RS-iSer(3-Ph)-OMe Structure

32981-85-4

Bz-RS-iSer(3-Ph)-OMe


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