Abstract Two metabolites of the tranquilizer azaperone were extracted from alkalinized horse urine after treatment with β-glucuronidase/sulfatase from limpets (Patella vulgata). The metabolites were identified by a combination of independent chemical synthesis and GC/MS and 1 H NMR analysis. The metabolites were identified as 1-(fluorophenyl)-4-[4-(5-hydroxy- 2-pyridinyl)-1-piperazinyl]-1-butanol, designated as 5′-hydroxy-azaperol, and 1-( ...
[Ting, Pauline C.; Lee, Joe F.; Zorn, Nicolas; Kim, Hyunjin M.; Aslanian, Robert G.; Lin, Mingxiang; Smith, Michelle; Walker, Scott S.; Cook, John; Van Heek, Margaret; Lachowicz, Jean Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 4 p. 985 - 988]
