Lead optimization of a pyridine-carboxamide series as DGAT-1 inhibitors

…, SS Walker, J Cook, M Van Heek, J Lachowicz

Index: Ting, Pauline C.; Lee, Joe F.; Zorn, Nicolas; Kim, Hyunjin M.; Aslanian, Robert G.; Lin, Mingxiang; Smith, Michelle; Walker, Scott S.; Cook, John; Van Heek, Margaret; Lachowicz, Jean Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 4 p. 985 - 988

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Citation Number: 4

Abstract

The structure–activity relationship studies of a novel series of carboxylic acid derivatives of pyridine-carboxamides as DGAT-1 inhibitors is described. The optimization of the initial lead compound 6 based on in vitro and in vivo activity led to the discovery of key compounds 10j and 17h.