Dual aromatase–sulfatase inhibitors based on the anastrozole template: synthesis, in vitro SAR, molecular modelling and in vivo activity

T Jackson, LWL Woo, MN Trusselle…

Index: Organic and Biomolecular Chemistry, , vol. 5, # 18 p. 2940 - 2952

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Citation Number: 49

Abstract

... Chemistry. ... between 6(a) and 4-(benzyloxy)phenol to form 17 (Scheme 3). Debenzylation followed to give the free phenol 18 which was ... Scheme 3 Reagents and conditions: (i) DEAD, triphenylphosphine polystyrene, 4-(benzyloxy)phenol, 82%; (ii) 5% Pd/C, THF–MeOH, 76%; ( ...