Enantiomerically pure amines by a new method: biotransformation of oxalamic esters using the lipase from Candida antarctica

DT Chapman, DHG Crout, M Mahmoudian…

Index: Chapman, Daniel T.; Crout, David H. G.; Mahmoudian, Mahmoud; Scopes, David I. C.; Smith, Paul W. Chemical Communications, 1996 , # 21 p. 2415 - 2416

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Citation Number: 23

Abstract

Many classes of compound have been successfully generated in enantiomerically pure form by biotransformation. 1 However, few methods are available for the production of enantiomer- ically pure amines. The Celgene Corporation has developed a process based on enzyme-catalysed transamination2 and ex- amples are known in which a lipase has been used to catalyse the stereoselective amidation of esters (see below). Given that so few ...