Tetrahedron Letters

Achiral β-amino alcohols as efficient ligands for the ruthenium-catalysed asymmetric transfer hydrogenation of sulfinylimines

D Guijarro, Ó Pablo, M Yus

Index: Guijarro, David; Pablo, Oscar; Yus, Miguel Tetrahedron Letters, 2011 , vol. 52, # 7 p. 789 - 791

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Citation Number: 19

Abstract

Some achiral β-amino alcohols have been shown as efficient ligands for the ruthenium- catalysed asymmetric transfer hydrogenation of N-(tert-butylsulfinyl) imines in isopropanol. The ruthenium complex prepared from [RuCl2 (p-cymene)] 2 (2.5 mol%) and 2-amino-2- methyl-1-propanol (5mol%) leads to α-branched chiral primary amines with very high optical purities (up to 98% ee) by the diastereoselective reduction of the imines followed by ...