Pentacyclic triterpenes. Part 3: Synthesis and biological evaluation of oleanolic acid derivatives as novel inhibitors of glycogen phosphorylase

J Chen, J Liu, L Zhang, G Wu, W Hua, X Wu…

Index: Chen, Jun; Liu, Jun; Zhang, Luyong; Wu, Guanzhong; Hua, Weiyi; Wu, Xiaoming; Sun, Hongbin Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 11 p. 2915 - 2919

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Citation Number: 111

Abstract

Oleanolic acid and its synthetic derivatives have been identified as novel inhibitors of glycogen phosphorylase. Within this series of compounds, 4 (IC50= 3.3 μM) is the most potent GPa inhibitor. Preliminary structure–activity relationships of the oleanolic acid derivatives are discussed.