Synthetic Communications

Improved Cs2CO3 promoted O-alkylation of acids

JP Parrish, EE Dueno, SI Kim…

Index: Parrish, Jay P.; Dueno, Eric E.; Kim, Seok-In; Jung, Kyung Woon Synthetic Communications, 2000 , vol. 30, # 15 p. 2687 - 2700

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Citation Number: 26

Abstract

Abstract Cesium carbonate mediated O-alkylation of carboxylic acids was efficiently carried out under mild in situ conditions to give the corresponding esters exclusively. Chiral templates including α-hydroxy and α-alkoxy acids were also converted to their corresponding esters with no observed racemization.