Organic letters

Enantioselective Copper-Catalyzed Formal [4+ 2] Cycloaddition of o-Aminophenol Derivatives with Propargylic Esters for Synthesis of Optically Active 3, 4-Dihydro-2 …

ZT Liu, YH Wang, FL Zhu, XP Hu

Index: Jiang, Yan; Liu, Li-Xin; Yuan, Wei-Cheng; Zhang, Xiao-Mei Synlett, 2012 ,  vol. 23,  # 12  p. 1797 - 1800

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Citation Number: 5

Abstract

The first copper-catalyzed asymmetric formal [4+ 2] cycloaddition of o-aminophenol derivatives with propargylic esters as the bis-electrophilic C2 synthons for the stereoselective construction of chiral 2, 3, 4-trisubstituted 2 H-1, 4-benzoxazines bearing an