Syntheses of 4-Alkylidene-and 4-Aralkylidene-2-chloromethyl-5-oxazolones and N-(Chloroacetyl) dehydroamino Acids

H Kurita, Y Chigira, M Masaki, M Ohta

Index: Kurita,H. et al. Bulletin of the Chemical Society of Japan, 1968 , vol. 41, # 11 p. 2758 - 2762

Full Text: HTML

Citation Number: 8

Abstract

Treatment of N-dichloroacetyl amino acids with acetic anhydride at a temperature between 85° C and 130° C yielded 4-alkylidene-and 4-aralkylidene-2-chloromethyl-5-oxazolones, which were readily hydrolyzed to give 2-(2-chloroacetamido)-2-alkenoic acids, ie, N- (chloroacetyl)-dehydroamino acids.