Nucleosides, Nucleotides and Nucleic Acids

1??Deaza??5′??noraisteromycin

X Yin, SW Schneller

Index: Yin, Xueqiang; Schneller, Stewart W Nucleosides, nucleotides and nucleic acids, 2004 , vol. 23, # 1-2 p. 67 - 76

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Citation Number: 5

Abstract

(±)??1??Deazaaristeromycin (4) has been reported to be an inactivator of S?? adenosylhomocysteine (AdoHcy) hydrolase and, as a consequence, to affect S?? adenosylmethionine (AdoMet) mediated macromolecular biomethylations. To extend this to our program focused on 5′??noraristeromycin derivatives as inhibitors of the same hydrolase enzyme as potential antiviral agents, both enantiomers of 1??deaza??5′?? ...