Chemical Communications

A reductase-mimicking thiourea organocatalyst incorporating a covalently bound NADH analogue: efficient 1, 2-diketone reduction with in situ prosthetic group …

B Procuranti, SJ Connon

Index: Procuranti, Barbara; Connon, Stephen J. Chemical Communications, 2007 , # 14 p. 1421 - 1423

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Citation Number: 29

Abstract

Enzymatic manipulation of the NAD(P) + /NAD(P)H redox couple in biotransformations is a fundamental competency common to all living cells. 1 In biological systems levels of these cofactors are maintained through both continual degradation/biosynthesis 2 and the coupling of oxidation/reduction reactions to sustain a redox balance. 1,2 A considerable difficulty associated with the exploitation of biocatalytic reduction in preparative chemistry has been the need for the use of stoichiometric ...