Synthesis and evaluation of diaryl sulfides and diaryl selenide compounds for antitubulin and cytotoxic activity

…, AMM Antunes, MM Marques, M de FC Matos…

Index: Dos Santos, Edson Dos A.; Hamel, Ernest; Bai, Ruoli; Burnett, James C.; Tozatti, Camila Santos Suniga; Bogo, Danielle; Perdomo, Renata T.; Antunes, Alexandra M.M.; Marques, M. Matilde; Matos, Maria De F.C.; De Lima, Denis P. Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 16 p. 4669 - 4673

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Citation Number: 17

Abstract

Abstract We have devised a procedure for the synthesis of analogs of combretastatin A-4 (CA-4) containing sulfur and selenium atoms as spacer groups between the aromatic rings. CA-4 is well known for its potent activity as an inhibitor of tubulin polymerization, and its prodrugs combretastatin A-4 phosphate (CA-4P) and combretastatin A-1 phosphate (CA-1P) are being investigated as antitumor agents that cause tumor vascular collapse in addition ...

~21%

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