The Journal of Organic Chemistry

Cycliacylation studies on 3, 5-disubstituted phenylalkanoic acids

MS Newman, JO Landers

Index: Newman,M.S.; Landers,J.O. Journal of Organic Chemistry, 1977 , vol. 42, # 15 p. 2556 - 2559

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Citation Number: 4

Abstract

The syntheses of 4-(3-chloro-5-methylphenyl) butanoic acid (I), 4-(3-methoxy-5- methylphenyl) butanoic acid (4), 3-(3-chloro-5-methylphenyl) propanoic acid (7), and 3-(3- methoxy-5-methylphenyl) propanoic acid (10) are described. The ring closure of these acids to mixtures of 6, 8-disubstituted tetralones and 5, 7-disubstituted indanones by five reagents (anhydrous HF, polyphosphoric acid, AlC13 on RCOCl in benzene and in nitroethane, ...