Synthetic analogues of the manzamenones and plakoridines which inhibit DNA polymerase

…, H Ryan, R Takeuchi, K Sakaguchi, A Sardarian…

Index: Doncaster, Jeremy R.; Etchells, Laura L.; Kershaw, Neil M.; Nakamura, Ryoichi; Ryan, Hazel; Takeuchi, Ryo; Sakaguchi, Kengo; Sardarian, Ali; Whitehead, Roger C. Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 11 p. 2877 - 2881

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Citation Number: 10

Abstract

An array of novel analogues of the marine oxylipins, the manzamenones and plakoridines, have been prepared in divergent fashion using an approach modelled on a biogenetic theory. Many of the target compounds show potent inhibition of DNA polymerases α and β and human terminal deoxynucleotidyl transferase (TdT).