Conversion of 4??amino??4H??1, 2, 4??triazole to 1, 3??bis (1H??azol??l??yl)??2??aryl??2??propanols and 1??phenacyl??4??[(benzoyl or 4??toluenesulfonyl)??imino]??(1H??1, 2, 4?? …

…, DR Chapman, SP Upadhyaya, L Bauer

Index: Narayanan; Chapman; Upadhyaya; Bauer Journal of Heterocyclic Chemistry, 1993 , vol. 30, # 5 p. 1405 - 1412

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Citation Number: 22

Abstract

Abstract A series of 1, 3-bis (1H-azol-1-yl)-2-aryl-2-propanols 17 were synthesized in an one- pot procedure by reacting l-aryl-2-(1H-1, 2, 4-triazol-l-yl)-or l-aryl-2-(1H-imidazol-l-yl) ethanones with dimethylsulfoxonium methide in the presence of either 1, 2, 4-triazole or imidazole. The aromatic groups in 17 were either 4-bromo-, 4-chloro-, 2, 4-dichloro-or 2, 4- difluorophenyl. 4-Amino-4H-1, 2, 4-triazole was acylated with either benzoyl or 4-toluene- ...