Chemistry Letters

Regiospecific synthesis of 1-substituted 1, 2, 4-triazoles involving isomerization of the corresponding 4-substituted compounds.

K Smith, A Small, MG Hutchings

Index: Smith, Keith; Small, Andrew; Hutchings, Michael G. Chemistry Letters, 1990 , # 3 p. 347 - 350

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Citation Number: 13

Abstract

On heating with a catalytic quantity of the corresponding alkyl or phenacyl halides, 4-alkyl-or 4-phenacyl-1, 2, 4-triazoles isomerize via quaternary salts to their 1-substituted isomers. Thus, the 1-substituted compounds can now be obtained regiospecifically from 1, 2, 4- triazole by alkylation-isomerization.