In this study, 1R, 2R-dicamphanoyl-3, 3-dimethydihydropyrano [2, 3-c] xanthen-7 (1H)-one (DCX) derivatives were designed and synthesized as novel anti-HIV agents against both wild-type and non-nucleoside reverse transcriptase (RT) inhibitor-resistant HIV-1 (RTMDR- 1) strains. Twenty-four DCX analogs (6–29) were synthesized and evaluated against the non-drug-resistant HIV-1 NL4-3 strain, and selected analogs were also screened for their ...
