ARKIVOC

Regioselective synthesis and antimicrobial evaluation of new 1-aryloxyacetyl-, 1-thiophenoxyacetyl-and 1-phenylaminoacetyl-substituted 3-alkyl (aryl/heteroaryl …

HG Bonacorso, EP Pittaluga, SH Alves, LF Schaffer…

Index: Bonacorso, Helio G.; Pittaluga, Everton P.; Alves, Sydney H.; Schaffer, Larissa F.; Cavinatto, Susiane; Porte, Liliane M. F.; Paim, Gisele R.; Martins, Marcos A. P.; Zanatta, Nilo Arkivoc, 2012 , vol. 2012, # 8 p. 62 - 75

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Citation Number: 4

Abstract

Abstract This paper describes an efficient approach for the regioselective synthesis of new series of twenty 1-aryloxy (thio) acetyl and 1-(phenylamino) acetyl-substituted 5- trifluoromethyl-5-hydroxy-4, 5-dihydro-1H-pyrazoles (3) in 34–96% yields from the cyclocondensation reaction of 4-alkoxy-4-alkyl-(aryl/heteroaryl)-1, 1, 1-trifluoroalk-3-en-2- ones with different substituted acetohydrazides. Dehydration reactions of 3, carried out in ...