Photoinduced radical hydroperfluoroalkylation and the synthesis of fluorinated amino acids and peptides

…, K Yamaguchi, R Hirokane, E Nogami

Index: Yajima, Tomoko; Yamaguchi, Kanako; Hirokane, Rie; Nogami, Emiko Journal of Fluorine Chemistry, 2013 , vol. 150, p. 1 - 7

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Citation Number: 16

Abstract

The photoinduced radical hydroperfluoroalkylation of unsaturated carboxylic acids using TTMSS as a H-donor was successfully developed. The stereoselective reaction using Oppolzer's camphorsultum was also achieved to give high stereoselectivity. The reaction was also effective for N-phthalimide-dehydroamino acid and the product was easily converted to the corresponding amino acid and a peptide derivative.