Tetrahedron letters

A simple and regioselective conversion of terminal acetylene into 2-substituted acrylonitrile

FT Luo, SL Ko, DY Chao

Index: Luo, Fen-Tair; Ko, Sheng-Li; Chao, Dean-Yang Tetrahedron Letters, 1997 , vol. 38, # 46 p. 8061 - 8062

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Citation Number: 5

Abstract

The addition of hydrogen cyanide to alkynes catalyzed by transition metal complexes to form α,β-unsaturated nitriles are potentially useful in organic synthesis.1, 2 and 3Although hydrogen cyanide can be generated in situ from acetone cyanohydrin to avoid the use of the poisinous hydrogen cyanide, [4]one or two moles of hydrogen cyanide may add to a triple bond, since the initial product is a Michael-type substrate which may easily undergo the second addition ...