A simple and highly efficient iron catalyst for a [2+ 2+ 2] cycloaddition to form pyridines

C Wang, X Li, F Wu, B Wan

Index: Wang, Chunxiang; Li, Xincheng; Wu, Fan; Wan, Boshun Angewandte Chemie - International Edition, 2011 , vol. 50, # 31 p. 7162 - 7166

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Citation Number: 84

Abstract

Transition-metal-catalyzed[2+ 2+ 2] cycloaddition reactions that use two alkynes and a nitrile is the most straightforward and powerful strategy for the construction of multisubstituted pyridines with high atom efficiency.[1, 2] The iron-catalyzed [2+ 2+ 2] cycloaddition to form pyridines remains a great challenge in this field,[3, 4] although significant efforts have been made in various catalytic systems (eg Co,[5] Ru,[6] Rh,[7] Ni,[8] Ti,[9] Zr/Ni [10]) in the last ...