Molecules

One-pot synthesis of 5-arylidene-2-imino-4-thiazolidinones under microwave irradiation

S Kasmi-Mir, A Djafri, L Paquin, J Hamelin…

Index: Kasmi-Mir, Souad; Djafri, Ayada; Paquin, Ludovic; Hamelin, Jack; Rahmouni, Mustapha Molecules, 2006 , vol. 11, # 8 p. 597 - 602

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Citation Number: 45

Abstract

: A rapid and easy solvent free one-pot synthesis of 5-arylidene-2-imino-4-thiazolidinones by condensation of the thioureas with chloroacetic acid and an aldehyde under microwave-irradiation is described. ... 4-Thiazolidinone derivatives constitute an important class of heterocyclic compounds for their potential pharmaceutical applications [1,2,3,4,5,6,7,8]. Consequently, a large number of synthetic protocols leading to these compounds have been reported in the literature [9]. ...