Synthesis of β-and γ-oxa isosteres of fosmidomycin and FR900098 as antimalarial candidates

…, J Wiesner, D Gießmann, T Verbrugghen…

Index: Haemers, Timothy; Wiesner, Jochen; Giessmann, Dirk; Verbrugghen, Thomas; Hillaert, Ulrik; Ortmann, Regina; Jomaa, Hassan; Link, Andreas; Schlitzer, Martin; Van Calenbergh, Serge Bioorganic and Medicinal Chemistry, 2008 , vol. 16, # 6 p. 3361 - 3371

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Citation Number: 53

Abstract

To expand the structure–activity relationships of fosmidomycin and FR900098, two potent antimalarials interfering with the MEP-pathway, we decided to replace a methylene group in β-position of the phosphonate moiety of these leads by an oxygen atom. β-oxa-FR900098 ...