A new highly asymmetric chelation-controlled Heck arylation

P Nilsson, M Larhed, A Hallberg

Index: Nilsson, Peter; Larhed, Mats; Hallberg, Anders Journal of the American Chemical Society, 2003 , vol. 125, # 12 p. 3430 - 3431

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Citation Number: 73

Abstract

This communication describes the development of a new highly asymmetric chelation- controlled Heck arylation. The methodology permits formation of 2-aryl-2-methyl cyclopentanones in good to very good two-step yields (45-78%) with excellent chiral enrichment (90-98% ee). In contrast to the well-known direct coupling to the enolate of a cyclic ketone, the Heck arylation of the corresponding N-methyl pyrrolidin enol ether ...