Direct geminal dimethylation of ketones using dimethyltitanium dichloride

MT Reetz, J Westermann, R Steinbach

Index: Reetz, Manfred T.; Westermann, Juergen; Steinbach, Rainer Journal of the Chemical Society, Chemical Communications, 1981 , # 5 p. 237 - 239

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Citation Number: 36

Abstract

By MANFRED T. REETZ,* JURGEN WESTERMANN, and RAINER STEINBACH (Fachbereich Chemie der Universitat, Hans-Meerwein-Strasse, 3 550 Marburg, W.-Germany) ... Summary Ketones are readily converted into the corre- sponding geminal dimethyl derivatives on reaction with dimethyltitanium dichloride under mild conditions ; tertiary alcohols react similarly. ... THE geminal dimethyl structural unit occurs frequently in terpenes, steroids, and other ...

~77%

~93%

~85%

~84%

~34%

… A deficient hamster tracheal organ cultures. Single-crysta...

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Conformationally restricted retinoids

[Dawson, Marcia I.; Hobbs, Peter D.; Derdzinski, Krzysztof; Chan, Rebecca L.-S.; Gruber, John; et al. Journal of Medicinal Chemistry, 1984 , vol. 27, # 11 p. 1516 - 1531]