Curcuminoids form reactive glucuronides in vitro

E Pfeiffer, SI Hoehle, SG Walch, A Riess…

Index: Pfeiffer, Erika; Hoehle, Simone I.; Walch, Stephan G.; Riess, Alexander; Solyom, Aniko M.; Metzler, Manfred Journal of Agricultural and Food Chemistry, 2007 , vol. 55, # 2 p. 538 - 544

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Citation Number: 64

Abstract

Curcumin is of current interest because of its putative anti-inflammatory, anticarcinogenic, and anti-Alzheimer's activity, but its pharmacokinetic and metabolic fate is poorly understood. The present in vitro study has therefore been conducted on the glucuronidation of curcumin and its major phase I metabolite, hexahydro-curcumin, as well as of various natural and artificial analogs. The predominant glucuronide generated by rat and human ...

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