Tetrahedron

A versatile radical based approach to O-alkylated hydroxylamines and oximes

B Quiclet-Sire, D Woollaston, SZ Zard

Index: Quiclet-Sire, Beatrice; Woollaston, Daniel; Zard, Samir Z. Tetrahedron, 2008 , vol. 64, # 52 p. 11917 - 11924

Full Text: HTML

Citation Number: 5

Abstract

O-Alkylhydroxylamines, often used for the preparation of bioconjugates, can be readily obtained by radical addition to suitable O-alkenylhydroxylamine derivatives. In the case of N- Boc-O-allylhydroxylamine, the addition is unexpectedly followed by elimination resulting in an overall allylation of the radical species.