Copper??Catalyzed Decarboxylative Three??Component Reactions for the Synthesis of Imidazo [1, 2??a] pyridines

…, K Park, MR Kumar, HM Jung, S Lee

Index: Palani, Thiruvengadam; Park, Kyungho; Kumar, Manian Rajesh; Jung, Hyun Ming; Lee, Sunwoo European Journal of Organic Chemistry, 2012 , # 26 p. 5038 - 5047

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Citation Number: 24

Abstract

Abstract Imidazo [1, 2-a] pyridine derivatives were synthesized through multicomponent coupling reactions of 2-aminopyridines, aldehydes, and alkynecarboxylic acids in the presence of 10 mol-% CuI/Cu (OTf) 2. Both aryl-and alkyl-substituted alkynecarboxylic acids, including propiolic acid, were good alkyne sources and afforded the desired imidazo [1, 2-a] pyridines in good yields through the decarboxylative coupling reactions. ...