Novel thiazole-based heterocycles as selective inhibitors of fibrinogen-mediated platelet aggregation

PJ Sanfilippo, P Andrade-Gordon…

Index: Sanfilippo; Urbanski; Beers; Eckardt; Falotico; Ginsberg; Offord; Press; Tighe; Tomko; Andrade-Gordon Journal of Medicinal Chemistry, 1995 , vol. 38, # 1 p. 34 - 41

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Citation Number: 29

Abstract

The synthesis and biological activity of novel thiazole-based heterocycles as inhibitors of thrombin-induced human platelet aggregation are described. Further evaluation of selected compounds show they inhibit platelet aggregation as stimulated by a variety of agonists. The more active compounds also were found to inhibit fibrinogen binding to platelets. To further delineate the mechanism of action of these compounds, direct binding studies with the ...