An original series of 4-substituted pyrrolo [1, 2-a] quinoxaline derivatives, new structural analogues of Galipea species quinoline alkaloids, was synthesized from various substituted 2-nitroanilines via multistep heterocyclizations and tested for in vitro antiparasitic activity upon Leishmania amazonensis and Leishmania infantum strains. Structure–activity relationships enlighten the importance of the 4-substituted alkenyl side chain on the ...
