Abstract A range of 1, 2, 4-oxadiazoles, having a carbamoyl group at the 3-position, were synthesized from 2-methyl-4-nitroisoxazolin-5 (2H)-one via three steps. Ammonolysis of this nitroisoxazolone afforded 2-amino-2-hydroxyimino-N-methylacetamide in excellent yield. O- Acylation of this key amidoxime, followed by ring closure, proceeded smoothly to give 3- carbamoyl-1, 2, 4-oxadiazoles having a substituent at the 5-position which could be easily ...
![[[1-amino-2-(methylamino)-2-oxoethylidene]amino] acetate Structure](https://image.chemsrc.com/caspic/292/918814-07-0.png)
