Synthesis and antibacterial activity of 3-substituted-5H-4-oxo-1, 2, 3-triazino [5, 4-b] indoles and 1, 1-dialkyl (1-aryl)-3-(2-ethoxycarbonylindol-3-yl) triazenes

…, LM Alekseeva, EN Padeiskaya, TP Radkevich…

Index: Nesterova, I. N; Velezheva, V. S.; Alekseeva, L. M.; Padeiskaya, E. N.; Radkevich, T. P; et al. Pharmaceutical Chemistry Journal, 1990 , vol. 24, # 11 p. 813 - 817 Khimiko-Farmatsevticheskii Zhurnal, 1990 , vol. 24, # 11 p. 36 - 40

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Abstract

In order to increase the yield of desired product and to simplify the method, we have carried out the step of diazotization of amine I in a 1.6: 1 mixture of DMF and water, diazoindole II was not isolated, and combination of the diazo solution with the amine component was carried out at pH 9, which parameter was maintained with an excess of reagent.