Synlett

Scope and utility of CsOH· H2O in amination reactions via direct coupling of aryl halides and sec-alicyclic amines

R Varala, E Ramu, MM Alam, SR Adapa

Index: Varala, Ravi; Ramu; Alam, M. Mujahid; Adapa, Srinivas R. Synlett, 2004 , # 10 p. 1747 - 1750

Full Text: HTML

Citation Number: 18

Abstract

Abstract Direct coupling of aryl halides with sec-alicyclic amines promoted by CsOH· H 2 O in DMSO to the corresponding aryl substituted amines, with good to excellent yields, is reported herein. A variety of aryl halides and sec-alicyclic amines with a broad range of electronic diversity and functional groups was studied in this transformation, thus offering general applicability in organic synthesis.