Transport of the highly charged myo-inositol hexakisphosphate molecule across the red blood cell membrane: a phase transfer and biological study

SP Vincent, JM Lehn, J Lazarte, C Nicolau

Index: Vincent, Stephane P; Lehn, Jean-Marie; Lazarte, Jaime; Nicolau, Claude Bioorganic and Medicinal Chemistry, 2002 , vol. 10, # 9 p. 2825 - 2834

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Citation Number: 17

Abstract

To address the problem of delivering highly charged small molecules, such as phytic acid (InsP6 or IHP), across biological membranes, we investigated an approach based on a non- covalent interaction between transport molecule (s) and IHP. Thus, we synthesized a collection of compounds containing IHP ionically bound to lipophilic (but non-lipidic) ammonium or poly-ammonium cations. First, we assessed the ability of these water- ...