Synthesis and study of the toxic and psychotropic properties of 3-dialkoxyphosphorylpropylglycidyl ethers

…, VI Petrov, AA Ozerov, AA Gunger, VA Sazhin

Index: Brel', A. K.; Petrov, V. I.; Ozerov, A. A.; Gunger, A. A.; Sazhin, V. A. Pharmaceutical Chemistry Journal, 1992 , vol. 26, # 9-10 p. 772 - 774 Khimiko-Farmatsevticheskii Zhurnal, 1992 , vol. 26, # 9-10 p. 86 - 87

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Abstract

Phosphorylated glycidyl ethers are convenient synthons allowing easy entry into known and new potential drug materials of lipophilic phosphonolipid fragments facilitating the transmembrane transport of biologically active sub~ strates. Modification of the amino group of neuroactive amino acids by phosphorylated glycidyl ethers leads to compounds with significant psychotropic properties [4]. The possible use of phosphorylated epoxides for ...