Selective copper (II) acetate and potassium iodide catalyzed oxidation of aminals to dihydroquinazoline and quinazolinone alkaloids

MT Richers, C Zhao, D Seidel

Index: Richers, Matthew T.; Zhao, Chenfei; Seidel, Daniel Beilstein Journal of Organic Chemistry, 2013 , vol. 9, p. 1194 - 1201

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Citation Number: 17

Abstract

Abstract Copper (II) acetate/acetic acid/O 2 and potassium iodide/tert-butylhydroperoxide systems are shown to affect the selective oxidation of ring-fused aminals to dihydroquinazolines and quinazolinones, respectively. These methods enable the facile preparation of a number of quinazoline alkaloid natural products and their analogues.