Assembly of ion channel mimics from a modular construction set

TM Fyles, TD James, A Pryhitka…

Index: Fyles; James; Pryhitka; Zojaji Journal of Organic Chemistry, 1993 , vol. 58, # 26 p. 7456 - 7468

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Citation Number: 49

Abstract

Ion channel mimics were assembled from a modular construction set consisting of core units, derived from polycarboxylate 18-crown-6 ethers, wall units, derived from macrocyclic tetraesters, and polar head groups which provide overall amphiphilic character. The preparation of symmetrical and side-discriminated macrocyclic tetraesters from diols and maleic anhydride gave the required macrocycles in low yields by acid-catalyzed ...