S, S-Dimethyl dithiocarbonate: A convenient reagent for the synthesis of symmetrical and unsymmetrical ureas

M Leung, JL Lai, KH Lau, H Yu…

Index: Leung, Man-Kit; Lai, Jun-Liang; Lau, King-Hang; Yu, Hsiao-Hua; Hsiao, Hsiang-Ju Journal of Organic Chemistry, 1996 , vol. 61, # 12 p. 4175 - 4179

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Citation Number: 74

Abstract

The condensation of primary amines with phosgene or isocyanates is a classic method for the synthesis of organic ureas. 1 However, due to their high toxicity and reactivity, phosgene and isocyanates are difficult to handle in the laboratory. Although several substitutes for phosgene such as triphosgene and carbonyldiimidazole have been developed during the last few decades, 2, 3 these reagents are themselves prepared from phosgene. ...