Synthesis and antidepressant activity of 4-aryltetrahydrothieno [2, 3-c] pyridine derivatives

…, H Daniel, WD Bechtel, K Boeke-Kuhn

Index: Schneider; Weber; Daniel; Bechtel; Boeke-Kuhn Journal of Medicinal Chemistry, 1984 , vol. 27, # 9 p. 1150 - 1155

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Citation Number: 16

Abstract

Tricyclic antidepressants such as imipramine or ami- triptyline are most frequently used in the treatment of endogenous depre~sion.l-~ Their ability to inhibit the uptake of norepinephrine (NE) and 5-hydroxytryptamine (5-HT) into the presynaptic nerve terminal has generally been predictive of antidepressant action in man.4*6 However, these drugs have undesirable anticholinergic6 or cardiotoxic side effects7+ that seem to be related to their tricyclic structure. ...