2, 4, 5-Trisubstituted imidazoles: novel nontoxic modulators of P-glycoprotein mediated multidrug resistance. Part 21

…, EJ Moran, S Krane, JC Rodarte, KD Benbatoul…

Index: Zhang, Chengzhi; Sarshar, Sepehr; Moran, Edmund J.; Krane, Sonja; Rodarte, Jennifer C.; Benbatoul, Khalid D.; Dixon, Ross; Mjalli, Adnan M.M. Bioorganic and Medicinal Chemistry Letters, 2000 , vol. 10, # 23 p. 2603 - 2605

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Citation Number: 46

Abstract

Over the last decade, the development of in vitro MDR modulators has been remarkably successful, yet to date no agent has displayed significant clinical efficacy. 6 This is largely due either to the inherent toxicity of these compounds or to the heightened toxicity of the antineoplastic agents when co-administered with the modulator. ... In the preceding article, we described a novel class of 2,4,5-trisubstituted imidazoles (A) with potent Pgp inhibitory profile. 7 We ...