Discussion The biological data for 3c are summarized in Table I1 along with the corresponding results obtained with a standard arylacetic acid antiinflammatory agent, ibuprofen. Comparison of these results indicates that 3c possesses oral activity in the primary test system, Le., mouse active Arthus (MAA), with an ID,= 342 mg/kg and is approximately 10 times more potent when administered via the intraperitoneal route, ie, ID ...