Caulerpenyne–colchicine hybrid: Synthesis and biological evaluation

…, L Commeiras, P Barbier, V Bourgarel-Rey…

Index: Bourdron, Julien; Commeiras, Laurent; Barbier, Pascale; Bourgarel-Rey, Veronique; Pasquier, Eddy; Vanthuyne, Nicolas; Hubaud, Jean-Claude; Peyrot, Vincent; Parrain, Jean-Luc Bioorganic and Medicinal Chemistry, 2006 , vol. 14, # 16 p. 5540 - 5548

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Citation Number: 17

Abstract

Tubulin, the major structural component of microtubules, participates actively in mitotic spindle formation and chromosomal organization during cell division. Thus, this protein is a target of anti-mitotic drugs called anti-tubulin agents. Since only a few molecules like taxoids or Vinca-alkaloids are used for cancer chemotherapy, a lot of energy is being spent in finding new anti-mitotic drugs. One of the approaches consists in the synthesis and analysis of ...

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