Synthesis of reduced collagen crosslinks

AMCH van den Nieuwendijk, JCJ Benningshof…

Index: Van den Nieuwendijk, Adrianus M.C.H.; Benningshof, Jorg C. J.; Wegmann, Volker; Bank, Ruud A.; Te Koppele, Johan M.; Brussee, Johannes; Van der Gen, Arne Bioorganic and Medicinal Chemistry Letters, 1999 , vol. 9, # 12 p. 1673 - 1676

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Citation Number: 6

Abstract

A new synthetic route to reduced collagen crosslinks (LNL and HLNL) is described in this report. It enables an enantioselective synthesis of LNL. HLNL was obtained as a mixture of two diastereoisomers. This method also provides the possibility to introduce radio-labels during the synthesis.

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