Chemoselective deprotection of silyl ethers by DIBALH

…, S Ishihara, N Ohtani, M Satake, K Tachibana

Index: Kuranaga, Takefumi; Ishihara, Shuji; Ohtani, Naohito; Satake, Masayuki; Tachibana, Kazuo Tetrahedron Letters, 2010 , vol. 51, # 48 p. 6345 - 6348

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Citation Number: 8

Abstract

Silyl ethers, such as the TES (triethylsilyl) group, the TBS (tert-butyldimethylsilyl) group, and the TBDPS (tert-butyldiphenylsilyl) group are the most widely used protective groups for alcohols because of the facility for selective protection and deprotection. Selective introduction of silyl ethers is achieved by controlling the reaction conditions, for example, the solvent, temperature, reaction time, base, amount of the reagents, and so on. Similarly, many ...