New N-pyridinyl (methyl)-indolalkanamides acting as topical inflammation inhibitors

…, J Evano, M Duflos, G le Baut, N Grimaud…

Index: Dassonville, Alexandra; Breteche, Anne; Evano, Johan; Duflos, Muriel; Le Baut, Guillaume; Grimaud, Nicole; Petit, Jean-Yves Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 21 p. 5441 - 5444

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Citation Number: 5

Abstract

The authors have described the synthetic way to new N-pyridinyl (methyl) indolylpropanamides acting as non acidic NSAIDs. Pharmacomodulation was carried out at N-1 and C-5 of the indole ring and at the level of the propanamide chain. N-(pyridin-3- ylmethyl)-3-[5-chloro-1-(4-chlorobenzyl)-indol-3-yl] propanamide 32 represents one of the most potent compounds evaluated in the TPA-induced mouse ear swelling assay, with a ...