2-Amino-aryl-7-aryl-benzoxazoles as potent, selective and orally available JAK2 inhibitors

M Gerspacher, P Furet, C Pissot-Soldermann…

Index: Bioorganic and Medicinal Chemistry Letters, , vol. 20, # 5 p. 1724 - 1727

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Citation Number: 13

Abstract

... Please enable JavaScript to use all the features on this page. Bioorganic & Medicinal Chemistry Letters. ... 7 As shown in Table 2, 15 has a low clearance and low volume of distribution at steady state (V SS ) and a terminal t 1/2 of 3.2 h after iv administration to rats. ...