Inhibition of Matrix Metalloproteinases: An examination of the S1′ pocket

…, P Huxley, FM Martin, L Saroglou, AJ Thompson…

Index: Miller, Andrew; Askew, Marion; Beckett, R. Paul; Bellamy, Claire L.; Bone, Elisabeth A.; Coates, Rachael E.; Davidson, Alan H.; Drummond, Alan H.; Huxley, Philip; Martin, Fionna M.; Saroglou, Lydia; Thompson, Alison J.; Van Dijk, Sonja E.; Whittaker, Mark Bioorganic and Medicinal Chemistry Letters, 1997 , vol. 7, # 2 p. 193 - 198

Full Text: HTML

Citation Number: 27

Abstract

Download full text in PDF Opens in a new window. Article suggestions will be shown in a dialog on return to ScienceDirect. ... Please enable JavaScript to use all the features on this page. ... Peptidomimetic carboxylate- and hydroxamate-based inhibitors of matrix metalloproteinases containing extended P1′ groups have been prepared. Potent inhibition and good selectivity for MMP-2 has been observed for the compounds produced.