These results are particularly interesting in view of the few reported direct monoalkylation of uracil. I-Benzyluracil has been synthesized by direct monoalkylation with benzyl chloride of uracil in aqueous sodium hydroxide! The reduction of the 56-double bond of N-alkylated uracils with lithium tris-s-butylborohydride afforded the corresponding 5, Gdihydro derivatives and the method also could be used for alkylation of the 5-position of n- ...
