Design and synthesis of novel stiripentol analogues as potential anticonvulsants

…, KM Amin, M Abdel-Rehim, MF El-Behairy

Index: Aboul-Enein, Mohamed N.; El-Azzouny, Aida A.; Attia, Mohamed I.; Maklad, Yousreya A.; Amin, Kamilia M.; Abdel-Rehim, Mohamed; El-Behairy, Mohammed F. European Journal of Medicinal Chemistry, 2012 , vol. 47, # 1 p. 360 - 369

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Citation Number: 41

Abstract

A series of stiripentol (STP) analogues namely, 2-[(1E)-1-(1, 3-benzodioxol-5-yl)-4, 4- dimethylpent-1-en-3-ylidene]-N-(aryl/H) hydrazinecarboxamides 7a–h,(±)-(5RS)-N-(aryl/H)- (1, 3-benzodioxol-5-yl)-3-tert-butyl-4, 5-dihydro-1H-pyrazole-1-carboxamides (±)-8a–h, and (±)-[(5RS)-(1, 3-benzodioxol-5-yl)-3-tert-butyl-4, 5-dihydro-1H-pyrazol-1-yl](aryl) methanones (±)-13a–f was synthesized by adopting appropriate synthetic routes and was ...